Dr. James Wilson.  You have to love Wilson.  There are hardly any aspects of his personality that are bad.  Throughout the series, we see Wilson and his numerous failed relationships.  Almost every one of the females complained that he was to “caring” or “considerate.”  That’s almost a paradox if you think about it.  How can you be to caring?  It is speculated many times by House, that Wilson feels like he needs to “fix” the women he marries, or even dates.  Then when they actually adjust, he moves on.  Hence the reason he can’t stay in a relationship.

Wilson is pretty much the only friend House has.  This is where the Holmes/House and Watson/Wilson comparison comes in.  If you’ve read any of the Sherlock Holmes novels by Sir Arthur Conan Doyle, you’ll know that House’s and Wilson’s relationship is almost if not exactly identical to Wilson’s and Holmes’s.  It’s very interesting to re-watch and observe the comparison.  Wilson, in some ways, is opposite of House.  He obviously cares for patients 1000% more.  He isn’t opposite in all ways, though.  He knows how to manipulate, as we see in the episode “House vs. God,” where he talks House’s patient into taking treatment for an illness.  House recognizes, and also loves this ability.  House once called Wilson a “a buddy of mine people say ‘Thank you’ to when he tells them they are dying.”

We see Wilson’s loyalty to House many times throughout the series, particularly when Vogler attempted to get House fired.  Wilson was the only one to vote against the termination of House, causing his dismissal as well.  However, he quickly comes back after Vogler is removed from the board, as they realize he is the donated money wasn’t worth the problems he was causing.

Wilson cares about House, obviously.  We see him attempt to fix House’s problems with Vicodin in many times throughout the series.  He even assisted Tritter, the detective investigating House’s drug problems.  He eventually was coaxed into testifying against House; however he did this simply for House’s gain more than anything.

It is revealed in Season four that Wilson was dating Amber (a.k.a. Cutthroat Bitch) which was one of House’s former students which qualified for the job on his team.  It was speculated by House, and also Cuddy that Wilson was only dating her because he wants a change from his typical neediness, but his need to be desired will feed off her need to control, and eventually it will destroy Wilson.

Overall, Wilson is a great character, and an excellent reflection of House in many ways, as well as a polar opposite.  In my opinion, they contrast each other quite well.